Peritubular C4d deposition is a significant predictor of long-term graft survival rates and to be of prognostic significance (6). Plasma level of C4d has been shown to be significantly higher in patients with antibody–associated vasculitis with active disease compared with patients with lupus nephritis and normal controls (5). In primary Sjogren’s syndrome (pSS) the level of C4d correlates with anti-SSB and κ/λ ratio and is suggested to be an appropriate marker of antibody response and complement activation in pSS patients with auto-antibodies (3,4). Particularly, C4d associates with SLE nephritis (2). The C4d protein is a product of the classical and the lectin pathways.Ĭ4d, a degradation end product produced during complement C4 activation, had been recognized as a biomarker for its stability and strong association with antibody-mediated rejection in the 1990s and in the last twenty years, the potential importance of C4d in SLE as a tool for diagnosing and monitoring SLE was highlighted (1). There are three pathways of complement activation the classical, the alternative and the lectin pathway. The complement system plays an essential role in autoimmune and infectious diseases. Complement C4d ELISA Kit Developed and Manufactured by Svar Life Science
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |